Differential Efficacy of Ketamine in the Acute versus Chronic Stages of Complex Regional Pain Syndrome in Mice.
MouseFractureTibiaC57BL/6JMalen = n=8-12 per group across 5 cohorts of miceSubcutaneous continuous infusion by osmotic minipump (Alzet 1007D, total volume 100 microlitres, delivery rate 0.5 microlitres/hour)2 mg/kg/dayPump inserted either 3 weeks after fracture (acute phase, 2 days after cast rem…
Model: Closed distal tibia fracture of the right hindlimb made with a haemostat followed by 3 weeks of hindlimb cast immobilisation, a model of complex regional pain syndrome
Ketamine infused 3 weeks after fracture did not alter limb temperature, oedema or mechanical thresholds, whereas infusion at 7 weeks produced anti-allodynia that persisted for 4 weeks after the infusion ended, reduced capsaicin-evoked behaviours at 18 weeks (mean difference -49.92, 95% CI -66.52 to…
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