Resolution of Inflammation by Resolvin D1 Is Essential for Peroxisome Proliferator-activated Receptor-gamma-mediated Analgesia during Postincisional Pain Development in Type 2 Diabetes.
MouseWounddb/db type 2 diabetic mice with m/m littermate controlsMalen = n=10 per groupLocal injection at the incision site
Model: Surgical skin incision (postincisional pain model) in type 2 diabetic db/db mice, with outcomes followed for 7 days after incision
Rosiglitazone plus resolvin D1 alleviated mechanical hyperalgesia in db/db mice whereas rosiglitazone alone did not (day 4: 0.506 plus or minus 0.106 versus 0.068 plus or minus 0.12; day 7: 0.529 plus or minus 0.184 versus 0.153 plus or minus 0.183). The combination markedly reduced local neutrophi…
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