A novel thermosensitive in-situ gel of gabexate mesilate for treatment of traumatic pancreatitis: An experimental study.
RatOtherSprague-DawleyMaleLocal injection of the in-situ gel (local intramuscular injection used for the safety assessment)Gabexate mesilate concentrations of 1.0, 5.0, 10.0 and 20.0…
Model: Traumatic pancreatitis with grade II pancreas injury
Trypsin activity was slightly inhibited at 1.0 and 5.0 mg/mL and completely inhibited at 10.0 and 20.0 mg/mL. Amylase, C-reactive protein and trypsinogen activation peptide were raised in traumatic pancreatitis and were slightly reduced by 1.0 and 5.0 mg/mL gel (p<0.05) and significantly reduced by…
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