Assessment of the neuroprotective effects of the acetylcholinesterase inhibitor huperzine A in an experimental spinal cord trauma model.

Assessment of the neuroprotective effects of the acetylcholinesterase inhibitor huperzine A in an experimental spinal cord trauma model.

Model: Spinal cord clip compression injury (moderate static clip compression, 70 g for 60 s, at T7 level)

Huperzine A treatment significantly reduced the number of apoptotic cells (P<0.01) and necrotic cells with more normal appearing neurons compared with untreated trauma groups. BBB scores showed improved locomotor performance in the treated group relative to controls.

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