Trigeminal Pain Molecules, Allodynia, and Photosensitivity Are Pharmacologically and Genetically Modulated in a Model of Traumatic Brain Injury.
MouseTBIControlled cortical impactC57BL (from MeSH indexing); wild-type and inducible nitric oxide synthase (iNOS) knockout miceMaleTreatment effects compared with vehicle at 2 weeks post injury; genetic compari…
Model: Controlled cortical impact traumatic brain injury, used as a model of post-traumatic headache
MK8825 and sumatriptan both increased allodynic thresholds after controlled cortical impact compared with vehicle (P<0.01) and reduced iNOS messenger RNA and immunoreactivity in the trigeminal nucleus caudalis and ganglia (P<0.01). Photosensitivity was attenuated by MK8825 and in iNOS knockouts (P<…
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