Promotion of acute-phase skin wound healing by Pseudomonas aeruginosa C-HSL.
RatWoundSprague-DawleyFemaleApplied to the wound surface (anti-C-HSL antiserum given by intraperitoneal injection)
Model: Dorsal skin wound inoculated with Pseudomonas aeruginosa PAO1 or its rhlI or lasI deletion mutants
PAO1 inoculation significantly accelerated wound healing with neutrophil infiltration and TNF-alpha synthesis, and this acceleration was lost with the rhlI deletion mutant or with anti-C-HSL antiserum. C-HSL applied without PAO1 accelerated healing and neutrophil infiltration without increasing TNF…
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