Evidence & regulatory context
- Mechanism
- compound_search 'N-butanoyl-L-homoserine lactone' returned 0 ChEMBL records. search_trials 'homoserine lactone' returned 0 human trials. Bacterial quorum-sensing autoinducer with no clinical translation; both zeroes are searched results, not assumptions.
- Target
- Not recorded
- Injury models
- Wound
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatWoundSprague-DawleyFemaleApplied to the wound surface (anti-C-HSL antiserum given by intraperitoneal injection)
Model: Dorsal skin wound inoculated with Pseudomonas aeruginosa PAO1 or its rhlI or lasI deletion mutants
PAO1 inoculation significantly accelerated wound healing with neutrophil infiltration and TNF-alpha synthesis, and this acceleration was lost with the rhlI deletion mutant or with anti-C-HSL antiserum. C-HSL applied without PAO1 accelerated healing and neutrophil infiltration without increasing TNF…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
