Ameliorative effect of naringin against doxorubicin-induced acute cardiac toxicity in rats.
RatChemical/toxinWistarMaleIntraperitoneal50 and 100 mg/kgStarted 10 days before doxorubicin and continued after it (naringin from day 0…
Model: Doxorubicin-induced acute cardiotoxicity (doxorubicin 15 mg/kg intraperitoneally as a single dose on day 10)
Doxorubicin increased cardiac MDA and decreased GSH, SOD, catalase and mitochondrial complex I-IV activities (P<0.05). Naringin 100 mg/kg significantly decreased MDA (P<0.001), raised GSH, SOD and catalase (P<0.001) and increased mitochondrial complex I (P<0.01), II (P<0.001), III (P<0.001) and IV…
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