Effects of Long-term Regular Grapefruit Juice Consumption on Vascular Protection and Bone Metabolism: Cross-over Study to Determine the Specific Role of Naringin
Post-menopausal Status
Enrolment: 52 · Results not recorded
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Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Post-menopausal Status
Enrolment: 52 · Results not recorded
Weight Loss
Enrolment: 75 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Acute acrolein inhalation (10 ppm for 12 hours) induced pulmonary injury
Naringin given before acrolein exposure significantly improved airspace enlargement and lung inflammation and mitigated MAPK, p53 and NF-kappaB signalling markers as well as oxidative damage markers.
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.
Model: Hindlimb ischaemia and reperfusion of skeletal muscle
Naringin reduced malondialdehyde and antioxidant enzyme activity changes and lessened muscle degeneration and inflammation compared with ischaemia-reperfusion alone.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Doxorubicin-induced acute cardiotoxicity (doxorubicin 15 mg/kg intraperitoneally as a single dose on day 10)
Doxorubicin increased cardiac MDA and decreased GSH, SOD, catalase and mitochondrial complex I-IV activities (P<0.05). Naringin 100 mg/kg significantly decreased MDA (P<0.001), raised GSH, SOD and catalase (P<0.001) and increased mitochondrial complex I (P<0.01), II (P<0.001), III (P<0.001) and IV…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.