Erythropoietin Pretreatment Attenuates Seawater Aspiration-Induced Acute Lung Injury in Rats.
RatOtherSprague-Dawley (from MeSH indexing)MaleIntraperitonealPretreatment, at 48 h and 24 h before seawater aspiration
Model: Seawater aspiration-induced acute lung injury
EPO pretreatment increased arterial partial oxygen tension and reduced lung histological injury scores after seawater aspiration. It also attenuated the seawater-induced increases in pulmonary NF-kappa B p65, inducible nitric oxide synthase, caspase-3, TNF-alpha, IL-1beta, myeloperoxidase activity…
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