Acute Treatment of Resveratrol Alleviates Doxorubicin-Induced Myotoxicity in Aged Skeletal Muscle Through SIRT1-Dependent Mechanisms.
MouseChemical/toxinSenescence-accelerated mouse prone 8 (SAMP8)Male
Model: Doxorubicin-induced skeletal muscle myotoxicity in young and aged senescence-accelerated mice
Resveratrol attenuated doxorubicin-induced increases in apoptotic and catabolic markers in aged skeletal muscle, and these benefits were abolished by the SIRT1 inhibitors sirtinol or EX527. Insulin signalling markers were unaffected by either doxorubicin or resveratrol.
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