Delayed administration of recombinant human erythropoietin reduces apoptosis and inflammation and promotes myelin repair and functional recovery following spinal cord compressive injury in rats.
RatSpinal cord injuryCompressionSprague-DawleyMale3,000, 4,000 or 5,000 U/kgDelayed administration after injury, exact delay not stated in the abstract
Model: Acute thoracic spinal cord compressive injury
Delayed rhEPO reduced apoptosis and inflammation, promoted myelin repair and improved functional recovery. The greatest locomotor and histopathological improvement and the best myelin protection occurred at 5,000 U/kg, while 3,000, 4,000 and 5,000 U/kg gave similar ultrastructural protection and si…
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