Protective effect of nitric oxide in aristolochic acid-induced toxic acute kidney injury: an old friend with new assets.
MouseChemical/toxinC57BL/6JMaleOral, supplemented in drinking water5% in drinking waterGiven in association with aristolochic acid intoxication, exact start point not…
Model: Aristolochic acid nephropathy induced by daily intraperitoneal aristolochic acid 2.5 mg/kg for 4 days
L-arginine supplementation significantly increased nitric oxide bioavailability and improved both renal function and renal structure after aristolochic acid intoxication, with reduced Nox2 expression, lower reactive oxygen species production and increased antioxidant concentrations.
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