Hepatic expression of serum amyloid A1 is induced by traumatic brain injury and modulated by telmisartan.
MouseTBIControlled cortical impactC57BL/6Male1 hour post-injury
Model: Controlled cortical impact traumatic brain injury with assessment of the hepatic acute-phase response
Controlled cortical impact induced SAA1 in plasma by 6 hours and in liver by 1 day post-injury, with increased hepatic leukocyte infiltration, apoptosis and CXCL1 and CXCL10 expression, and an increase in AT1 receptor mRNA at 3 days. Telmisartan given 1 hour post-injury significantly decreased live…
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