THERAPY DOSSIER · th-51605383a889

Telmisartan

Drug · Angiotensin II type-1 (AT1) receptor antagonist (ANTAGONIST); partial PPAR-gamma agonist

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Angiotensin II type-1 (AT1) receptor antagonist (ANTAGONIST); partial PPAR-gamma agonist
Target: Type-1 angiotensin II receptor (AGTR1, CHEMBL227)
Injury models: TBI
Reported indication: Not recorded
First approval: 1998
Development stage: Not recorded
ChEMBL record: CHEMBL1017 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Telmisartan; Micardis; Pritor; BIBR-277
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02738632 ↗PHASE3completed

Telmisartan/Amlodipine/HCTZ vs Telmisartan/Amlodipine for Essential Hypertension

Essential Hypertension

Enrolment: 300 · Results not recorded

NCT00614380 ↗PHASE3completed

Chronic Telmisartan + Amlodipine Combination in Patients With Hypertension

Hypertension

Enrolment: 976 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26435412 ↗2015Mixed findings

Hepatic expression of serum amyloid A1 is induced by traumatic brain injury and modulated by telmisartan.

MouseTBIControlled cortical impactC57BL/6Male1 hour post-injury

Model: Controlled cortical impact traumatic brain injury with assessment of the hepatic acute-phase response

Controlled cortical impact induced SAA1 in plasma by 6 hours and in liver by 1 day post-injury, with increased hepatic leukocyte infiltration, apoptosis and CXCL1 and CXCL10 expression, and an increase in AT1 receptor mRNA at 3 days. Telmisartan given 1 hour post-injury significantly decreased live…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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