Effect of estrogen on recovering the injured nervous system.
RatSpinal cord injuryUnspecifiedSprague-Dawleyn = 72 adult rats in total, divided between a simple injury gro…Intramuscular injection100 micrograms per kgStarted after spinal cord injury, exact first dose timing not stated
Model: Acute spinal cord injury
Estrogen shifted the Bcl-2 expression peak from day 3 to day 8, reduced apoptosis of neurons and glial cells, and gave higher Gale scores and inclined plate maintenance rates than injury alone at 2 weeks. Animals were assessed at 1, 3, 5, 8, 14 and 21 days after injury.
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