PRECLINICAL PUBLICATION · 2015

Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Allogeneic bone marrow stromal cells, some genetically modified to secrete brain-derived neurotrophic factor (BDNF)

PMID 26414795 ↗2015No effect reported

Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury.

RatSpinal cord injuryCompressionSprague-DawleyFemaleIntraspinal transplantation into the injury site48 hours after the original injury

Model: Severe compressive spinal cord injury

Bone marrow stromal cell grafts, with or without BDNF secretion, failed to improve motor outcomes 2 months after severe compressive spinal cord injury, suggesting these cells do not act through local mechanisms.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.