THERAPY DOSSIER · th-dfadee250e44

Allogeneic bone marrow stromal cells, some genetically modified to secrete brain-derived neurotrophic factor (BDNF)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00695149 ↗Injury indicationPHASE1/PHASE2terminated

Treatment for Acute Spinal Cord Injury Using Cultured Bone Marrow Stromal Cells

Spinal Cord Injury

Enrolment: 5 · Results not recorded

NCT01446640 ↗Injury indicationPHASE1/PHASE2unknown

Autologous Bone Marrow-Derived Mesenchymal Stem Cells in Spinal Cord Injury

Spinal Cord Injury

Enrolment: 20 · Results not recorded

NCT02165904 ↗Injury indicationPHASE1completed

Subarachnoid Autologous Mesenchymal Stromal Cells in Incomplete Spinal Cord Injury

Spinal Cord Injury

Enrolment: 10 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26414795 ↗2015No effect reported

Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury.

RatSpinal cord injuryCompressionSprague-DawleyFemaleIntraspinal transplantation into the injury site48 hours after the original injury

Model: Severe compressive spinal cord injury

Bone marrow stromal cell grafts, with or without BDNF secretion, failed to improve motor outcomes 2 months after severe compressive spinal cord injury, suggesting these cells do not act through local mechanisms.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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