Amelioration of nicotinamide adenine dinucleotide phosphate-oxidase mediated stress reduces cell death after blast-induced traumatic brain injury.
RatTBIBlast / overpressureSprague DawleyMaleAfter blast injury (acute and subacute assessment)
Model: Single and repetitive blast-induced traumatic brain injury (validated rodent blast model)
Alpha-lipoic acid prevented acute superoxide formation, increased antiapoptotic markers Bcl-2 (t = 3.079, P < 0.05) and haem oxygenase 1 (t = 8.169, P < 0.001) after single blast, reduced Bax (t = 4.483, P < 0.05), caspase 12 (t = 6.157, P < 0.001) and caspase 3 (t = 4.573, P < 0.01) and tau hyperp…
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