Fresh frozen plasma reduces edema in skeletal muscle following combined limb ischemia-reperfusion injury and hemorrhagic shock in rats.
RatIschaemia-reperfusionLimb / skeletal muscleSprague DawleyIntravenous resuscitationVolume equal to the shed blood volume (lactated Ringer's gi…After 30 minutes of ischaemia
Model: 37.5% arterial haemorrhage producing haemorrhagic shock followed by 3 hours of tourniquet-induced hindlimb ischaemia-reperfusion
Fresh frozen plasma reduced muscle oedema by 13% compared with lactated Ringer's solution (p = 0.02), but pathology scores did not differ between treatment groups. Mortality was 50% in non-resuscitated rats.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.