Hyperoxic resuscitation improves survival but worsens neurologic outcome in a rat polytrauma model of traumatic brain injury plus hemorrhagic shock.
RatTBIControlled cortical impactSprague DawleyMalen = 10 per group across three groups (sham, polytrauma normoxic…Inhalation100% inspired oxygenDuring resuscitation after traumatic brain injury and haemorrhagic shock
Model: Controlled cortical impact traumatic brain injury followed by 30 minutes of haemorrhagic shock (mean arterial pressure 35 to 40 mm Hg)
Survival was greater with hyperoxic than normoxic resuscitation, but neurological outcome was worse: composite neuroscores at 2 to 4 weeks were lower than sham and balance beam foot faults at 2 weeks were greater than with normoxic resuscitation. Cerebrocortical pathology did not differ between nor…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.