THERAPY DOSSIER · th-7bc987f2bb17

Hyperoxic resuscitation with 100% inspired oxygen

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 8

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02673931 ↗Injury indicationNAactive not recruiting

MODALITY-level surrogate: restrictive versus liberal oxygen supply in cardiac surgery

Coronary Disease · Cardiogenic Shock · Renal Failure · Stroke · Brain Injury

Enrolment: 1400 · Results not recorded

NCT02321072 ↗PHASE4completed

Effects of hyperoxia on organ dysfunction and outcome in critically ill patients with SIRS

Systemic Inflammatory Response Syndrome

Enrolment: 400 · Results not recorded

NCT01889823 ↗PHASE1completed

Effects of oxygen status (hyperoxia) on hypoxia inducible factor 1-alpha and inflammation

Hypoxia · Hyperoxia

Enrolment: 20 · Results not recorded

NCT01881243 ↗Phase not recordedcompleted

Reoxygenation after cardiac arrest (REOX Study)

Cardiac Arrest

Enrolment: 280 · Results not recorded

NCT01781793 ↗NAcompleted

MODALITY-level surrogate: hyperoxia arm in mechanisms of exertional dyspnoea in fibrotic interstitial lung disease

Interstitial Lung Disease With Fibrosis

Enrolment: 20 · Results not recorded

NCT05550454 ↗NAcompleted

MODALITY-level surrogate: manual versus automatic mechanical ventilation during cardiopulmonary resuscitation

Out-Of-Hospital Cardiac Arrest · Advanced Cardiac Life Support

Enrolment: 60 · Results not recorded

NCT01629186 ↗NAcompleted

MODALITY-level surrogate: nasopharyngeal oxygen with nose-close and abdomen-compression in paediatric bronchoscopy

Bradycardia · Hypoxemia

Enrolment: 156 · Results not recorded

NCT04698863 ↗Phase not recordedcompleted

MODALITY-level surrogate: oxygenation assessed with oxygen reserve index at different fresh gas flows

Hyperoxia

Enrolment: 2 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26406421 ↗2015Mixed findings

Hyperoxic resuscitation improves survival but worsens neurologic outcome in a rat polytrauma model of traumatic brain injury plus hemorrhagic shock.

RatTBIControlled cortical impactSprague DawleyMalen = 10 per group across three groups (sham, polytrauma normoxic…Inhalation100% inspired oxygenDuring resuscitation after traumatic brain injury and haemorrhagic shock

Model: Controlled cortical impact traumatic brain injury followed by 30 minutes of haemorrhagic shock (mean arterial pressure 35 to 40 mm Hg)

Survival was greater with hyperoxic than normoxic resuscitation, but neurological outcome was worse: composite neuroscores at 2 to 4 weeks were lower than sham and balance beam foot faults at 2 weeks were greater than with normoxic resuscitation. Cerebrocortical pathology did not differ between nor…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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