Mesenchymal stem cells reverse bone marrow dysfunction following injury and stress.
RatCrushOther / unspecifiedSprague DawleyMalen = 6 to 7 per groupIntravenousWithin 10 minutes following lung contusion
Model: Unilateral lung contusion alone or lung contusion followed by chronic restraint stress
Adding mesenchymal stem cells to lung contusion plus chronic stress increased bone marrow cellularity by 22%, significantly increased CFU-GEMM, BFU-E and CFU-E colony growth, reduced plasma granulocyte colony-stimulating factor and prevented prolonged progenitor mobilisation to peripheral blood.
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