Rapamycin Improves Mortality Following Intestinal Ischemia-Reperfusion via the Inhibition of Remote Lung Inflammation in Mice.
MouseIschaemia-reperfusionIntestinal / mesentericC57BL/6MaleIntraperitoneal injection5 mg/kg1 hour before ischaemia
Model: Intestinal ischaemia-reperfusion by occlusion of the superior mesenteric artery for 1 hour
Rapamycin improved survival after intestinal ischaemia-reperfusion. Intestinal injury and inflammation were similar between groups, but lung injury and inflammation were significantly attenuated, with reduced lung bacterial burden and increased alveolar macrophage phagocytic activity.
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