Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection.
RatSpinal cord injuryComplete transectionSprague DawleyFemaleIntraparenchymal delivery at the injury site (intrathecal delivery also tested)1 U, 5 U, 50 U and 100 U compared; intrathecal 50 U was let…Sub-acute stage after injury
Model: Complete spinal cord transection
Low-dose chondroitinase ABC (1 U or 5 U) gave no functional recovery, whereas high dose (50 U or 100 U) delivered intraparenchymally reduced chondroitin sulfate proteoglycan levels and lesion size, increased axonal outgrowth across the lesion with Fluoro-Gold labelling of sensory and motor brainste…
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