Preclinical evidence 6
6 studies reported at therapy level; 6 evidence entries itemised.
MouseSpinal cord injuryComplete transectionYFP-H transgenicIntraspinal deliveryAcutely post-injury or after one month delay
Model: Unilateral rubrospinal tract transection
Both acute and delayed ChABC treatment rescued rubrospinal neurons from atrophy, reversing chronic cell-body atrophy after spinal cord injury.
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RatSpinal cord injuryHemisection / partialMaleIntraspinal (into lesion)4 weeks after injury (chronic)
Model: C4 dorsal spinal cord injury (chronic)
Chondroitinase ABC combined with task-specific rehabilitation given 4 weeks after injury improved skilled forelimb function in chronic spinal cord injury.
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RatSpinal cord injuryCompressionWistarMaleIntrathecal (catheter)2, 3 and 4 days after injury
Model: Spinal cord compression injury
Intrathecal chondroitinase ABC decreased NG2 and enhanced GAP-43 axonal regrowth after spinal cord injury but did not significantly improve motor function.
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RatSpinal cord injuryContusionMaleApplied at acute and at chronic time points after injury
Model: Severe midcervical contusion spinal cord injury
ChABC applied at chronic time points restored normal breathing activity in previously paralysed inspiratory muscles and reduced compensatory activity elsewhere in the respiratory motor system, whereas acute application recovered only modest respiratory function. Lesion cavity size was unchanged by…
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MouseTBIControlled cortical impactC57BL/6Malen = 40 mice in total, n = 10 per groupIntracerebroventricular injection into the right lateral ventricle, needle to 3 mm depth at 1 mm right and 0.3 mm anterior to bregma10 microlitres of filter-sterilised 50 U/ml chondroitinase…Within 5 min after injury
Model: Controlled cortical impact through a 5 mm craniotomy, 3 mm flat cylindrical indenter driven to 1.3 mm depth at 5 m/s with 300 ms dwell at 10 degrees to the vertical
Injury raised ipsilateral water fraction by 1.13 per cent relative to the contralateral hemisphere; treatment reduced ipsilateral water fraction by 0.54 per cent (p < 0.05), eliminating almost half the injury-induced oedema, with no significant effect in uninjured animals.
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RatSpinal cord injuryComplete transectionSprague DawleyFemaleIntraparenchymal delivery at the injury site (intrathecal delivery also tested)1 U, 5 U, 50 U and 100 U compared; intrathecal 50 U was let…Sub-acute stage after injury
Model: Complete spinal cord transection
Low-dose chondroitinase ABC (1 U or 5 U) gave no functional recovery, whereas high dose (50 U or 100 U) delivered intraparenchymally reduced chondroitin sulfate proteoglycan levels and lesion size, increased axonal outgrowth across the lesion with Fluoro-Gold labelling of sensory and motor brainste…
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