Nafamostat mesilate attenuates transient focal ischemia/reperfusion-induced brain injury via the inhibition of endoplasmic reticulum stress.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague DawleyMaleIntravenous1 mg/kgAdministered before and after the middle cerebral artery occlusion procedure
Model: Transient middle cerebral artery occlusion with reperfusion
Nafamostat mesilate significantly decreased infarct size and brain oedema, attenuated neuronal degeneration and glial activation, and reduced expression of the endoplasmic reticulum stress markers GRP78, CHOP and phosphorylated eIF2alpha.
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