Investigation of acute effects of Hypericum perforatum (St. John's Wort-Kantaron) treatment in experimental thermal burns and comparison with silver sulfadiazine treatment.
RatBurnScaldWistarFemalen = 35 rats, 7 per group across five groupsTopicalWithin the first 24 hours after burn, following 3 minutes of irrigation with 50…
Model: Second-degree thermal scald burn created on the dorsum by exposing a 4 x 4 cm area to 100 degrees C boiled water for 10 seconds
Hypericum perforatum limited collagen discolouration to the lower epidermal layer, preserved epidermis, hair follicles and sebaceous glands, and gave significantly greater epidermal thickness and vessel number and fewer degenerated hair follicles than the other groups (p < 0.05), with total hair fo…
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