THERAPY DOSSIER · th-1217ae8760d8

Hypericum perforatum (St John's Wort) extract

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07012278 ↗Injury indicationNArecruiting

Effect of St. John's Wort Oil on Wound Healing and Pain in Women Undergoing Cesarean Section

Wound Healing · Caesarean Section

Enrolment: 80 · Results not recorded

NCT00006395 ↗PHASE4completed

Effect of St. John's Wort on Single Dose Carbamazepine Pharmacokinetics

Healthy

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26388268 ↗2015Reported benefit

Investigation of acute effects of Hypericum perforatum (St. John's Wort-Kantaron) treatment in experimental thermal burns and comparison with silver sulfadiazine treatment.

RatBurnScaldWistarFemalen = 35 rats, 7 per group across five groupsTopicalWithin the first 24 hours after burn, following 3 minutes of irrigation with 50…

Model: Second-degree thermal scald burn created on the dorsum by exposing a 4 x 4 cm area to 100 degrees C boiled water for 10 seconds

Hypericum perforatum limited collagen discolouration to the lower epidermal layer, preserved epidermis, hair follicles and sebaceous glands, and gave significantly greater epidermal thickness and vessel number and fewer degenerated hair follicles than the other groups (p < 0.05), with total hair fo…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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