CISD2 serves a novel role as a suppressor of nitric oxide signalling and curcumin increases CISD2 expression in spinal cord injuries.
RatSpinal cord injuryContusionSprague DawleyMaleIntraperitoneal40 mg/kg in vivo; 1 micromolar in vitroAfter acute spinal cord injury
Model: Acute traumatic spinal cord injury in rats, with lipopolysaccharide-challenged neural cell culture as an in vitro inflammation model
Spinal cord injury reduced CISD2 mRNA and protein expression in vivo and curcumin treatment upregulated CISD2-positive cells. Curcumin at 1 micromolar attenuated LPS-induced CISD2 downregulation in vitro, and CISD2 knockdown produced a pronounced increase in iNOS with decreased BCL2.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.