Ameliorative potential of standardized fruit extract of Pterodon pubescens Benth on neuropathic pain in mice: Evidence for the mechanisms of action.
MouseOtherFemaleIntragastric (oral)30 to 300 mg/kg
Model: Partial sciatic nerve ligation induced neuropathic pain
EEPp reduced mechanical and thermal hyperalgesia after partial sciatic nerve ligation without inducing tolerance, inhibited nociceptive responses to glutamatergic agonists, proinflammatory cytokines and TRPV1 and TRPA1 activators, and showed a cumulative effect over 24 hours on day 15 of prolonged…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.