Chronic Alcohol Exposure Enhances Lipopolysaccharide-Induced Lung Injury in Mice: Potential Role of Systemic Tumor Necrosis Factor-Alpha.
MouseEndotoxin/LPSMaleAdministered for the duration of alcohol exposure, before lipopolysaccharide ch…
Model: Lipopolysaccharide-induced acute lung and liver injury on a background of 6 weeks of chronic ethanol exposure (Lieber-DeCarli diet)
Chronic ethanol pre-exposure enhanced both liver and lung injury caused by lipopolysaccharide. Systemic TNF-alpha depletion with etanercept blunted the injury and the increase in MIP-2 and KC in the lung caused by the combination of ethanol and LPS.
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