A Single Bolus of Docosahexaenoic Acid Promotes Neuroplastic Changes in the Innervation of Spinal Cord Interneurons and Motor Neurons and Improves Functional Recovery after Spinal Cord Injury.
MixedSpinal cord injuryHemisection / partialSprague Dawley (rat)FemaleIntravenousAcute single bolus 30 minutes after injury
Model: Rat cervical hemisection spinal cord injury and mouse pyramidotomy
A single acute intravenous bolus of docosahexaenoic acid induced robust sprouting of uninjured corticospinal and serotonergic fibres, increased synaptophysin and contacts with V2a interneurons and motor neurons, upregulated miR-21 and phosphorylated AKT with downregulation of PTEN, and improved fun…
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