Acrolein contributes to TRPA1 up-regulation in peripheral and central sensory hypersensitivity following spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyMaleIntraperitoneal5 mg/kgFirst dose within three minutes of injury, second dose 24 h after injury
Model: Contusion spinal cord injury at T10 using a New York University impactor, 10 g rod dropped from 25 mm onto intact dura after dorsal laminectomy; separate experiments used intraspinal acrolein micro-injection (40 nmol in 1.6 microlitres) and intraplantar acrolein injection (625 nmol in 25 microlitres)
Spinal cord injury raised TRPA1 mRNA in dorsal horn, dorsal root ganglia and paw skin, with an approximately 40-fold rise in paw skin. Daily hydralazine reduced this up-regulation at one week (dorsal horn 2.6 to 1.0 fold, dorsal root ganglia 2.0 to 1.2 fold, paw skin 41.4 to 0.60 fold) and at two w…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.