Trial title not recorded
Heart Failure, Congestive
Enrolment: 80 · Results not recorded
Loading the evidence…
Drug · Mode of action not fully understood; it seems to interfere with calcium release, leading to vasodilation
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Heart Failure, Congestive
Enrolment: 80 · Results not recorded
Heart Failure · Diabetes
Enrolment: 1100 · Results not recorded
Healthy
Enrolment: 16 · Results not recorded
Metastatic Cervical Cancer
Enrolment: 143 · Results not recorded
Cervical Cancer
Enrolment: 18 · Results not recorded
Hypertension · Cardiovascular Diseases
Enrolment not recorded · Results not recorded
Hypertension
Enrolment: 152 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Contusion spinal cord injury at T10 using a New York University impactor, 10 g rod dropped from 25 mm onto intact dura after dorsal laminectomy; separate experiments used intraspinal acrolein micro-injection (40 nmol in 1.6 microlitres) and intraplantar acrolein injection (625 nmol in 25 microlitres)
Spinal cord injury raised TRPA1 mRNA in dorsal horn, dorsal root ganglia and paw skin, with an approximately 40-fold rise in paw skin. Daily hydralazine reduced this up-regulation at one week (dorsal horn 2.6 to 1.0 fold, dorsal root ganglia 2.0 to 1.2 fold, paw skin 41.4 to 0.60 fold) and at two w…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: T10 contusion spinal cord injury by weight drop (NYU impactor, 10 g weight dropped 25 mm onto intact dura) after T10 laminectomy; a separate experiment used intraspinal microinjection of acrolein 1.6 microlitres into dorsal horn of uninjured rats
Spinal cord injury raised acrolein-lysine adducts at 1 day (39.43 +/- 2.46 arbitrary units) and 2 weeks (30.38 +/- 2.71) versus sham (9.68 +/- 4.67, P < 0.001), doubled dorsal root ganglion TRPA1 mRNA (2.03 +/- 0.11 fold), increased the proportion of acrolein responsive neurons from 38 to 58 percen…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.
Model: Acute arterial endothelial injury by aortic balloon denudation and carotid air injury
Myointimal thickening after arterial injury was markedly enhanced in hypertensive rats and was reduced by antihypertensive treatment, while endothelial regeneration was similar across groups.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.