Antinociceptive effect of 1400 W, an inhibitor of inducible nitric oxide synthase, following hind paw incision in rats.
RatWoundSprague-DawleyLocal administration into the wound, or intrathecal30 micrograms (fixed quantity)Local into the wound at the time of incision; intrathecal 15 min before incisio…
Model: Hind paw plantar incision (rodent model of postoperative pain), with chronic indwelling intrathecal catheters implanted in naive rats
Nitric oxide rose significantly locally between 4 h and day 1 and at the spinal level at 4 h after incision. Local iNOS inhibition transiently reduced guarding from 4 to 12 h, while spinal inhibition produced a more pronounced reduction of guarding and allodynia and lowered spinal nitric oxide. Dru…
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