THERAPY DOSSIER · th-40f70f3a8fa5

1400 W

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00845169 ↗NAcompleted

The Role of Nitric Oxide Synthase Isoforms in the Cardiovascular Effects of Air Pollution

Endothelial Dysfunction

Enrolment: 16 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26362773 ↗2015Reported benefit

Antinociceptive effect of 1400 W, an inhibitor of inducible nitric oxide synthase, following hind paw incision in rats.

RatWoundSprague-DawleyLocal administration into the wound, or intrathecal30 micrograms (fixed quantity)Local into the wound at the time of incision; intrathecal 15 min before incisio…

Model: Hind paw plantar incision (rodent model of postoperative pain), with chronic indwelling intrathecal catheters implanted in naive rats

Nitric oxide rose significantly locally between 4 h and day 1 and at the spinal level at 4 h after incision. Local iNOS inhibition transiently reduced guarding from 4 to 12 h, while spinal inhibition produced a more pronounced reduction of guarding and allodynia and lowered spinal nitric oxide. Dru…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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