Mesenchymal stem cell therapy in a rat model of birth-trauma injury: functional improvements and biodistribution.
RatCrushOther / unspecifiedSprague-Dawleyfemalen = 285 female Sprague-Dawley rats total; 270 underwent vaginal…Periurethral injection or systemic (intravenous) injection0.1 ml containing 1 million hMSCs per rat (10^6 cells/rat);…Immediately after vaginal distension
Model: Vaginal distension (serial dilation with 24-32 F bougie dilators then modified 10-F Foley catheter inflated with 3 cc sterile water for 4 h) simulating birth-trauma injury to the continence mechanism
Leak-point pressure after both systemic and periurethral hMSC treatment was comparable with non-distended controls at 4, 10 and 14 days, whereas saline and dermofibroblast controls were significantly lower at days 4 and 14. Connective tissue area proportion was higher in locally treated hMSC animal…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.