Rosiglitazone exerts neuroprotective effects via the suppression of neuronal autophagy and apoptosis in the cortex following traumatic brain injury.
RatTBIControlled cortical impactSprague-Dawleyfemalen = 150 rats: sham n=30, traumatic brain injury plus saline veh…Intraperitoneal injection2 mg/kgImmediately after traumatic brain injury
Model: Controlled cortical impact over the left parietal cortex through a 5 mm craniotomy, 2.5 mm rounded metal tip angled 22.5 degrees from vertical, velocity 4 m/s, deformation depth 2 mm below the dura
A single intraperitoneal dose of rosiglitazone given immediately after controlled cortical impact improved motor function recovery at days 1, 4 and 7, reduced caspase 3, Beclin-1 and LC3-II/LC3-I expression, increased Bcl-2, and lowered TNF-alpha and IL-6 in the cortex. No significant change was se…
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