The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid (SAHA) Confers Acute Neuroprotection After Intracerebral Hemorrhage in Mice.
MouseHaemorrhage/shockUnspecifiedmaleAfter induction of intracerebral haemorrhage
Model: Experimentally induced spontaneous intracerebral haemorrhage
SAHA-treated mice showed less neurodegeneration and improved neurological outcomes compared with vehicle-treated mice, together with reduced glial activation and lower expression of heme oxygenase-1, supporting a role for epigenetic mechanisms in neurological injury after intracerebral haemorrhage.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.