Bone marrow mesenchymal stem cell implantation for the treatment of radioactivity-induced acute skin damage in rats.
RatRadiationSprague-DawleymaleIntravenous (tail vein) followed by local multipoint injection at the injured area2 x 10^6 BMSCs in 1 ml by tail vein, then a second local mu…Tail vein injection immediately after irradiation; local injection two weeks la…
Model: Radiation-induced acute skin damage produced by irradiating the hind legs with a linear accelerator at 45 Gy
Skin damage was milder and healing faster in the BMSC group than in controls, with a significantly lower wound score (P<0.05). PGE2 and TGF-beta1 expression were significantly lower and SDF-1 expression significantly higher in the BMSC group (P<0.05), consistent with reduced inflammation and fibros…
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