Hepatoprotective activity of total iridoid glycosides isolated from Paederia scandens (lour.) Merr. var. tomentosa.
RatChemical/toxinSprague-DawleymaleOral administrationPre-treatment for 15 days before carbon tetrachloride challenge
Model: Acute liver injury induced by intraperitoneal injection of 10% carbon tetrachloride (0.12% v/v in olive oil, 10 mL/kg body weight)
Total iridoid glycosides significantly decreased serum AST and ALT compared with control rats, alleviated liver tissue injury on histology, significantly increased hepatic GSH, catalase and superoxide dismutase activity and decreased malondialdehyde, indicating hepatoprotection through reduced oxid…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.