THERAPY DOSSIER · th-58eb41221878

Total iridoid glycosides (TG) from Paederia scandens (Lour.) Merr. var. tomentosa

Nutraceutical · Crude multi-component plant extract; no defined ChEMBL entity, so ChEMBL was not queried. ClinicalTrials.gov searched for 'Paederia scandens OR iridoid glycosides': 0 hits (explicit negative result). No human trial administers this extract.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Crude multi-component plant extract; no defined ChEMBL entity, so ChEMBL was not queried. ClinicalTrials.gov searched for 'Paederia scandens OR iridoid glycosides': 0 hits (explicit negative result). No human trial administers this extract.
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26320683 ↗2015Reported benefit

Hepatoprotective activity of total iridoid glycosides isolated from Paederia scandens (lour.) Merr. var. tomentosa.

RatChemical/toxinSprague-DawleymaleOral administrationPre-treatment for 15 days before carbon tetrachloride challenge

Model: Acute liver injury induced by intraperitoneal injection of 10% carbon tetrachloride (0.12% v/v in olive oil, 10 mL/kg body weight)

Total iridoid glycosides significantly decreased serum AST and ALT compared with control rats, alleviated liver tissue injury on histology, significantly increased hepatic GSH, catalase and superoxide dismutase activity and decreased malondialdehyde, indicating hepatoprotection through reduced oxid…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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