Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro-Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice.
MouseTBIControlled cortical impactC57BL/6N and nerve growth factor receptor (p75NTR)-deficient miceIntravenous bolus24 hours after controlled cortical impact
Model: Controlled cortical impact traumatic brain injury
Propofol sedation given 24 hours after controlled cortical impact increased lesion volume, alpha-II-spectrin cleavage and perilesional cell death, and significantly impaired motor function at 30 days after injury. Propofol raised the pro-BDNF to BDNF ratio, and its toxicity was abolished by pharmac…
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