Patient-Controlled Sedation (propofol + alfentanil) in Port Implantation (PACSPI-2)
Pain · Patient Satisfaction · Cancer · Venous Puncture
Enrolment: 340 · Results not recorded
Loading the evidence…
Drug · GABA-A receptor anion channel positive allosteric modulator (POSITIVE ALLOSTERIC MODULATOR)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Pain · Patient Satisfaction · Cancer · Venous Puncture
Enrolment: 340 · Results not recorded
Obesity · Bariatrics · Sleep Apnea Syndromes · Gastric Bypass · Endoscopy
Enrolment: 22 · Results not recorded
Cerebral Arterial Disease · Cerebral Aneurysm
Enrolment: 50 · Results not recorded
Gastroscopy
Enrolment: 400 · Results not recorded
Surgery With General Anesthesia
Enrolment: 180 · Results not recorded
Postoperative Pain
Enrolment: 100 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Controlled cortical impact traumatic brain injury
Propofol sedation given 24 hours after controlled cortical impact increased lesion volume, alpha-II-spectrin cleavage and perilesional cell death, and significantly impaired motor function at 30 days after injury. Propofol raised the pro-BDNF to BDNF ratio, and its toxicity was abolished by pharmac…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Controlled cortical impact traumatic brain injury
Propofol aggravated neurological dysfunction, increased 28-day mortality and impaired post-traumatic neurogenesis, with a significantly stronger effect at the high dose when given during trauma induction; the delayed post-trauma protocol also increased mortality and impaired neurological function a…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Controlled cortical impact traumatic brain injury
Propofol given shortly after controlled cortical impact significantly reduced brain oedema and suppressed aquaporin-4 expression, in association with lower interleukin-1beta and tumour necrosis factor-alpha. In cultured astrocytes propofol blocked cytokine-driven aquaporin-4 induction by inhibiting…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.