Foreign Body Reaction to Implantable Biosensors: Effects of Tissue Trauma and Implant Size.
RatOtherSprague-DawleyMaleSubcutaneous implantation, needle gauges 14 and 16Coating present on the implant at the time of insertion
Model: Subcutaneous implantation of coated dummy sensors and glucose sensors using needles of different gauge, producing graded insertion trauma
The degree of acute inflammation was determined mainly by the extent of the initial insertion trauma rather than implant size, whereas chronic inflammation and fibrous encapsulation were greater with larger sensors. Sensors implanted with 14 gauge needles had significantly lower initial in vivo res…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.