Chronic Degeneration Leads to Poor Healing of Repaired Massive Rotator Cuff Tears in Rats.
Model: Unilateral dual tenotomy of the supraspinatus and infraspinatus tendons with intramuscular botulinum toxin A to induce chronic degeneration, repaired 8 weeks later; the contralateral shoulder underwent acute dual tendon injury with immediate repair. Repair used a 5-0 Prolene modified Mason-Allen stitch through an anteroposterior bone tunnel near the greater tuberosity
All repairs were intact with no gapping or suture disruption in either group. Chronic injury and repair produced approximately 25% less trabecular bone volume and 9% lower bone volume fraction than acute injury and repair, with significantly reduced tissue mineral density, fewer trabeculae and incr…
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