THERAPY DOSSIER · th-4d0aaafcf5c5

Surgical tendon-to-bone repair of chronic versus acute massive rotator cuff tears

Procedure · Surgical procedure (not a ChEMBL entity); tendon-to-bone rotator cuff repair

Evidence & regulatory context

Mechanism: Surgical procedure (not a ChEMBL entity); tendon-to-bone rotator cuff repair
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01987973 ↗NAcompleted

Arthroscopic Repair of Chronic Two-tendon Rotator Cuff Tears by Human Dermal Allograft

Rotator Cuff Tear

Enrolment: 29 · Results not recorded

NCT04248751 ↗NAunknown

Bioinductive Augmentation for High Risk Rotator Cuff Tears

Rotator Cuff Tear

Enrolment: 76 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26297522 ↗2015Reported harm

Chronic Degeneration Leads to Poor Healing of Repaired Massive Rotator Cuff Tears in Rats.

RatOtherSprague-DawleyMalen = 17 adult male Sprague-Dawley rats in total; biomechanical t…Intramuscular injection into the supraspinatus and infraspinatus muscle bellies; open surgical repairBotulinum toxin A 2.5 U per muscle in 50 microlitres of sal…Botulinum toxin A at the time of tendon release; repair at 8 weeks after injury…

Model: Unilateral dual tenotomy of the supraspinatus and infraspinatus tendons with intramuscular botulinum toxin A to induce chronic degeneration, repaired 8 weeks later; the contralateral shoulder underwent acute dual tendon injury with immediate repair. Repair used a 5-0 Prolene modified Mason-Allen stitch through an anteroposterior bone tunnel near the greater tuberosity

All repairs were intact with no gapping or suture disruption in either group. Chronic injury and repair produced approximately 25% less trabecular bone volume and 9% lower bone volume fraction than acute injury and repair, with significantly reduced tissue mineral density, fewer trabeculae and incr…

Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.

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