Role of melatonin, melatonin receptors and STAT3 in the cardioprotective effect of chronic and moderate consumption of red wine.
MixedIschaemia-reperfusionCardiacWistar rats; C57BL/6 wild-type mice; TNF receptor 2 knockout mice; cardiomyocyte-specific STAT3-deficient miceOral, in drinking water (red wine and melatonin); intraperitoneal (luzindole and prazosin)Melatonin given at the concentration found in the red wine;…Pre-treatment for 14 days before ischaemia-reperfusion
Model: Myocardial ischaemia-reperfusion injury in vivo and ex vivo (isolated heart)
Chronic moderate red wine consumption reduced infarct size in both rats and wild-type mice (p < 0.001). Luzindole did not affect the protection whereas prazosin reduced the infarct sparing effect (p < 0.05), and neither red wine nor melatonin protected TNF receptor 2 knockout or cardiomyocyte-speci…
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