The effect of vitamin E and L-carnitine against methotrexate-induced injury in rat testis.
RatChemical/toxinWistarMalen = Four groups including control; group sizes not statedIntraperitonealVitamin E 250 mg/kg; L-carnitine 500 mg/kg; control 0.5 mL/…Daily dosing from day 1, with methotrexate given on days 3 and 10
Model: Methotrexate-induced testicular injury, 20 mg/kg intraperitoneally on days 3 and 10 of a 17-day protocol
Methotrexate caused weight loss, testicular weight loss, marked histological injury, increased malondialdehyde and decreased superoxide dismutase. Vitamin E and L-carnitine did not prevent methotrexate-induced weight loss or testicular weight loss but inhibited the histological injury and suppresse…
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